Figure 3
DACT1 inhibits ovarian tumourigenesis in vivo. (a) 5 * 106 3AO-DACT1 or 3AO-NC cells were injected into the subcutaneous tissue of each nude mouse (n = 5 animals per group). Average tumour volume was assessed weekly (*P < 0.05, paired t test). (b) Representative images of xenografts five weeks after injection. (c) Five weeks after injection, xenograft tumours were resected and measured. The average weight of the DACT1 over-expressing xenograft tumours was significantly lower than that of control xenograft tumours (*P < 0.05). (d) and (e) Proliferation indexes of DACT1 over-expressing and control xenograft tumours were evaluated by Ki-67. Cell proliferation was significantly higher in control xenograft tumours than DACT1 over-expressing tumours (***P < 0.001).
