Figure 6 | Scientific Reports

Figure 6

From: Serum-derived extracellular vesicles (EVs) impact on vascular remodeling and prevent muscle damage in acute hind limb ischemia

Figure 6

Gene pattern and representative biological pathways associated with e-sEV and i-sEV administration. (A) Representative Venn diagram of up-regulated and down-regulated mRNA in ECs treated with e-sEVs and i-sEVs. 43 genes up-regulated after e-sEV treatment were down-regulated upon i-sEV treatment; 12 genes down-regulated after e-sEV treatment were up-regulated after i-sEV treatment; 20 genes up-regulated upon e-sEV treatment were up-regulated upon i-sEV treatment and 9 genes down-regulated after e-sEV treatment were down-regulated upon i-sEV treatment. The list of genes is reported in Supplementary Table S4. (B) GO analysis on significantly over-expressed genes induced by e-sEV treatment (genes with a fold increase ≥3 were included). The significant enrichment of TGFβ1-associated pathway was identified. (C) The histogram represents the comparison of GO signaling pathways related to genes reported in the Venn diagram and Supplementary Tables S3 and S4. Columns represent the % of gene clusters involved in each signaling pathway.

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