Table 3 Association analysis between polymorphisms of NER and PFS

Gene	SNP ID	Genetic Model^a	Genotype	MST	Log-rank P	Cox proportional hazards regression
Gene	SNP ID	Genetic Model^a	Genotype	MST	Log-rank P	HR	95%CI	P
POLD2	rs3757843		G G	7.6	0.007	1 (Reference)
			A G	11.6		0.75	0.63–0.91	0.003
			A A	8.7		0.95	0.66–1.37	0.788
		Dom			0.004	0.78	0.65–0.93	0.005
XPA	rs3176658		G G	8.1	0.027	1 (Reference)
			A G	11.0		0.82	0.68–0.98	0.028
			A A	10.3		0.77	0.53–1.10	0.149
		Dom			0.007	0.81	0.68–0.96	0.015
ERCC6	rs12571445		A A	9.2	0.030	1 (Reference)
			G A	7.2		1.21	0.97–1.52	0.090
			G G	—		0.13	0.02–0.96	0.045
		Rec			0.020	0.13	0.02–0.93	0.042
POLE	rs11609456		A A	7.8	0.009	1 (Reference)
			G A	11.6		0.76	0.62–0.94	0.011
			G G	13.7		0.79	0.35–1.78	0.573
		Dom			0.002	0.76	0.62–0.94	0.010
	rs5744751		G G	7.8	0.009	1 (Reference)
			A G	11.6		0.76	0.62–0.94	0.011
			A A	6.7		0.87	0.41–1.85	0.722
		Dom			0.003	0.77	0.62–0.94	0.011

Add, addictive model; Dom, dominant model; Rec, recessive model; MST, median survival time; HR, hazard ratio; CI, confidence interval; PFS, progression free survival.
^aThe best fitting model was shown.

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