Table 4 Association analysis between polymorphisms of NER and OS

From: Single nucleotide polymorphisms of nucleotide excision repair pathway are significantly associated with outcomes of platinum-based chemotherapy in lung cancer

Gene

SNP ID

Genetic Modela

Genotype

MST

Log-rank P

Cox proportional hazards regression

HR

95%CI

P

GTF2H4

rs3130780

 

C C

19.5

0.008

1 (Reference)

  
  

A C

17.0

 

1.06

0.84–1.34

0.639

  

A A

4.4

 

13.71

1.88–99.84

0.010

 

Rec

  

0.003

13.65

1.88–99.37

0.010

ERCC6

rs2281793

 

G G

19.3

0.018

1 (Reference)

  
  

A G

18.3

 

1.09

0.93–1.27

0.294

  

A A

23.0

 

0.73

0.55–0.96

0.025

 

Rec

  

0.007

0.70

0.53–0.91

0.009

GTF2H1

rs4150667

 

G G

14.2

0.041

1 (Reference)

  
  

A G

19.1

 

1.02

0.87–1.19

0.815

  

A A

20.2

 

1.37

1.06–1.78

0.016

 

Rec

  

0.017

1.36

1.06–1.75

0.015

MAT1

rs4151374

 

A A

18.1

0.037

1 (Reference)

  
  

G A

21.3

 

0.84

0.72–0.98

0.024

  

G G

18.0

 

0.99

0.77–1.27

0.936

 

Dom

  

0.036

0.86

0.75–0.99

0.049

POLD1

rs2546551

 

G G

19.0

0.005

1 (Reference)

  
  

A G

21.3

 

0.91

0.78–1.07

0.250

  

A A

12.5

 

1.79

1.12–2.87

0.016

 

Rec

  

0.002

1.84

1.15–2.94

0.011

  1. Dom, dominant model; Rec, recessive model. MST, median survival time; HR, hazard ratio; CI, confidence interval; OS, overall survival.
  2. aThe best fitting model was shown.
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