Figure 2 | Scientific Reports

Figure 2

From: RNA sequencing of db/db mice liver identifies lncRNA H19 as a key regulator of gluconeogenesis and hepatic glucose output

Figure 2

Representation of differentially expressed genes in the db/db mice liver. (a) Heatmap representing the expression pattern of 218 differentially expressed genes (as obtained from RNA sequencing) in the livers of diabetic (db/db) mice as compared to those of normal (db/+) mice. (b) Scatter plot comparing the mean expression profiles of all genes with FPKM >  = 1 in at least one sample within normal and diabetic mice liver. The significantly differentially altered genes (218) have been highlighted in red color, while the remaining are indicated in green color. (c) Bar plot summarizing the results of pathway enrichment analysis for the differentially expressed (DE) genes. The figure plots NLP (Negative Log10 of the Bonferroni-adjusted P-value) as well as the overlapping gene count for each pathway. The black vertical dotted line denotes a minimum gene overlap count cutoff of 2.

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