Figure 1

Changes of body weight and metabolic characteristics in HFD/STZ-treated TonEBP^+/− mice. (a) Body weights of mice for 20 weeks. Body weight (b), fat mass (c), body fats (d), GTT (e), areas under the curve (AUC) of GTT (f), ITT (g), and AUC of ITT (h) of WT and TonEBP^+/− mice with or without HFD/STZ treatment were compared. (i) Serum insulin was measured by an ELISA kit. HOMR-IR was calculated from fasting serum glucose and insulin. Data (n = 10 mice per group) are shown as the mean ± SEM. (j) Representative images showing immunofluorescence of insulin (red) in pancreatic sections. Scale bar = 50 μm. (k) Percentage areas of insulin-positive cells. Data are shown as the mean ± SEM. *P < 0.05 vs. control (CTL) normal diet-fed mice; ^† P < 0.05 vs. DM WT mice.