Figure 2

Clinical symptoms in monkeys after HPAIV challenge. (a) The vaccinated and unvaccinated monkeys were challenged with HPAIV (arrow). Fever onset was observed on the night of the day of challenge (black arrow heads). A second bout of fever was observed in the unvaccinated monkeys (gray arrow heads). Bodyweight (b) and respiratory rate (c) were monitored daily after the challenge. (d) Clinical symptoms were scored based on Supplemental Table 1. *p < 0.05, **p < 0.01, compared with the unvaccinated control on Dunnett’s test.