Figure 5
Newly discovered ggTas2r1 agonists, their predicted binding modes and functional data. In the 2D ligand-receptor interaction diagram, H-bond interactions are shown as magenta dashed arrows, salt bridges as blue-red lines, π−π interactions as green lines, cation−π interactions as red lines and hydrophobic interactions are represented as the distances between the closest heavy atoms of the ligand and the residue in orange dotted lines. Dose-response relations for the specified compounds in cells expressing native ggTas2r1: the y-axis shows the relative fluorescence changes (ΔF/F), and the x-axis the ligand concentration in μM.
