Figure 1 | Scientific Reports

Figure 1

From: Magnesium Chloride promotes Osteogenesis through Notch signaling activation and expansion of Mesenchymal Stem Cells

Figure 1

Effects of MgCl2 supplementation on osteogenesis and mineralization of rat MSC. (a) ALP activity was significantly and dose-dependently increased by Mg2+ concentration. (b) Matrix mineralization verified by Alizarin Red S staining was higher according to Mg2+ levels. (c) Osteogenic marker genes Runx2, (d) Osterix and (e) Osteocalcin expression was up-regulated according to the increase in Mg2+ concentrations. (f) Intact FGF23 in the liquid supernatant was increased according to Mg2+ concentrations. FGF23 was not detected in liquid supernatant of UC. UC - undifferentiated cells, OB - osteoblasts. Bars show mean ± SEM. n = 4.

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