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Figure 1

From: Octahedron Iron Oxide Nanocrystals Prohibited Clostridium difficile Spore Germination and Attenuated Local and Systemic Inflammation

Figure 1

C. difficile spore germination was significantly inhibited in spores treated with Fe3-δO4 nanoparticles. Purified CCUG 37780 spores were incubated in BHIS medium containing Fe3-δO4 nanoparticles ([500 µg/mL (▲), 50 µg/mL (), or 5 μg/mL (▵)]), or 3% sodium hypochlorite as a positive control. The kinetics of spore germination was analyzed using spectrometric absorption referenced to the starting point. OD600(T) = different time points after taurocholate treatment; OD600(T0) = time zero. Spore germination was significantly inhibited in spores treated with Fe3-δO4 nanoparticles. (***P < 0.001; one-way analysis of variance [ANOVA] followed by Tukey’s Multiple Comparison test).

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