Table 1 Neutrophilia induced by ray venom is modulated by innate molecules.

From: Stingray venom activates IL-33 producing cardiomyocytes, but not mast cell, to promote acute neutrophil-mediated injury

Ray Venom (2 h after i.p. injection)

Percentage of Neutrophils in Peritoneal Cavity (%)

Absolute Number of Neutrophils in Peritoneal Cavity (x105)

Negative-control

0

0

C57BL/6 WT

83.3*

23.3 ± 2.9*

Mast Cell KO

64.8

24.0 ± 3.7

ST2 KO

4.0 #

0.04 ± 0.5 #

AHR KO

81.7

23.7 ± 0.4

TLR2/TLR4 KO

44.7 #

2.7 ± 6.4 #

MyD88 KO

42.7 #

1.7 ± 1.8 #

TRIF KO

19.5 #

2.3 ± 1.8 #

NLRP3 KO

63.7

20.4 ± 3.4

ICE KO

76.7

19.2 ± 0.9

IL-1β KO

71.7

20.8 ± 2.5

P2RX7 KO

88.0

42.2 ± 1.4

CD39 KO

90.7

29.9 ± 0.6

IL-17RA KO

82.0

21.3 ± 0.3

IL-17A KO

14.3 #

0.2 ± 3.4 #

TBX21 KO

60.3

18.1 ± 3.6

IL-18R KO

48.8 #

11.7 ± 0.6 #

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