Figure 2
From: A combinatorial approach for the discovery of cytochrome P450 2D6 inhibitors from nature
(A) The pharmacophore model consisting of typical physicochemical features for CYP2D6 inhibitors. Chemical features are color-coded: hydrophobic - cyan, hydrogen bond acceptor - green, positively ionisable group - red, aromatic ring - orange, shape and size restriction - grey. (B) The 3D structure of the known inhibitor ajmalicine is fitted into the model.
