Figure 1 | Scientific Reports

Figure 1

From: Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts

Figure 1

Immunohistochemistry of HIF1α, VEGFA and ABCG2. Sections from paraffin embedded kidney biopsies with chronic kidney disease (normal (left) and reduced eGFR (right)) were stained with antibodies against HIF1α (A), ATP binding cassette subfamily G member 2 (ABCG2) (B), and vascular endothelial growth factor A (VEGFA) (C). (A) No specific HIF1α staining could be detected in kidney sections with normal eGFR, score negative (0). Only some unspecific intravascular background staining is seen (left). In kidneys from patients with severely reduced eGFR, some nuclear (→) and cytoplasmic (►) tubular staining is detected, score weak (1) (right). (B) ABCG2 showing strong (score 2) expression in the tubulointerstitial compartment of kidneys with normal eGFR (left) in contrast to weak (score 1) staining in samples with reduced eGFR (right). (C) Similar stainig pattern for VEGFA, strong (score 2) expression in the tubulointerstitial compartment of kidneys with normal eGFR (left) in contrast to weak (score 1) staining in samples with reduced eGFR (right).

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