Table 6 The Effect of HY and Non-HY Artificial Tear preparations on TBUT: Meta-Analytic Data of RCTs.
From: Sodium Hyaluronate in the Treatment of Dry Eye Syndrome: A Systematic Review and Meta-Analysis
Study | No. of subjects in HY arm | No. of subjects in Non-HY arm | Total | SMD | SE | 95% CI | t | P | Weight (%) | |
|---|---|---|---|---|---|---|---|---|---|---|
Fixed | Random | |||||||||
Baeyens et al.6 | 198 | 374 | 572 | 0.303 | 0.0882 | 0.129 to 0.476 | 51.72 | 12.65 | ||
Baudouin et al.7 | 29 | 37 | 66 | −0.00567 | 0.245 | −0.495 to 0.484 | 6.70 | 11.61 | ||
Lee et al.9 | 64 | 66 | 130 | −0.283 | 0.175 | −0.630 to 0.0634 | 13.10 | 12.17 | ||
Benellli et al.10 | 20 | 40 | 60 | −3.652 | 0.429 | −4.512 to −2.793 | 2.19 | 9.71 | ||
Sanchez et al.11 | 15 | 14 | 29 | −1.657 | 0.422 | −2.522 to −0.792 | 2.26 | 9.79 | ||
Brignole et al.14 | 10 | 11 | 21 | −0.515 | 0.427 | −1.408 to 0.378 | 2.21 | 9.74 | ||
Iester et al.18 | 58 | 55 | 113 | 0.245 | 0.188 | −0.127 to 0.617 | 11.44 | 12.08 | ||
Laflamme et al.21 | 12 | 24 | 36 | −0.363 | 0.348 | −1.071 to 0.345 | 3.32 | 10.59 | ||
Nelson et al.22 | 40 | 30 | 70 | 0.0557 | 0.239 | −0.421 to 0.532 | 7.05 | 11.66 | ||
Total (fixed effects) | 446 | 651 | 1097 | 0.0102 | 0.0635 | −0.114 to 0.135 | 0.161 | 0.872 | 100.00 | 100.00 |
Total (random effects) | 446 | 651 | 1097 | −0.566 | 0.271 | −1.099 to −0.0336 | −2.086 | 0.037 | 100.00 | 100.00 |
Test for heterogeneity | ||||||||||
Q | 14.4555 | |||||||||
DF | 6 | |||||||||
Significance level | P = 0.0249 | |||||||||
I2 (inconsistency) | 58.49% | |||||||||
95% CI for I2 | 4.19 to 82.02 | |||||||||
