Table 1 Characteristics of PID patients and HDs at time of MSC isolation.

From: Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency

BM-MSC samples

HD 15

CGD7

WAS 15

ADA 6

SCID 5 (3 RAG-1 deficiency, 2 γ-chain defect)

Median age (range) P value (HD age vs. pts. age)

8 years (2–15) P = NA

5 years (8 m–12 y) P = NS

3 years (6 m–12 y) P = NS

2 years (10 m–5 y) P < 0.05

2 years (6 m–3 y) P < 0.05

Males/Females

9 M/6 F

7 M

15 M

5 M/1 F

3 M/2 F

Genetics

NA

7/7 X-linked

15/15 X-linked

6/6 AR

3/5 AR

2/5 X-linked

  1. Abbreviations: BM, bone marrow; MSC, mesenchymal stromal cell; HD, healthy donor; CGD, chronic granulomatous disease; WAS, Wiskott-Aldrich syndrome; SCID, severe combined immune deficiency; ADA, adenosine deaminase deficiency; RAG, recombination activating gene; m, months; y, years; pts: patients; NA, not applicable; NS, not significant; M, males; F, females; NA, not available; AR, autosomal recessive.
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