Figure 8
Summary of effects of blocking Wnt/β-catenin signaling in sepsis. Wnt/β-catenin signaling is upregulated in macrophages after LPS stimulation and during sepsis, which then upregulates NF-κB signaling, resulting in increased systemic and local proinflammatory cytokines and chemokines, as well as increased collagen deposition, apoptosis and neutrophil infiltration in the lungs leading to organ injury. Treatment with iCRT3 blocks the Wnt/β-catenin signaling and reverses these changes attenuating sepsis-induced inflammatory responses and organ injury.
