Figure 3
From: Extracellular redox sensitivity of Kv1.2 potassium channels
Redox-sensitive use-dependence is transferrable in heteromeric channels containing Kv1.2 subunits. (A) Repetitive depolarizations were used to assess % use-dependent activation, as described in Fig. 1B, for a variety of Kv1 channel subtypes and concatenated combinations with Kv1.2 as indicated. Each data point reflects the % use-dependence recorded from an individual cell in ambient redox conditions (gray) or in the presence of either 666 µM or 2 mM DTT (blue). N = 10–17 for each construct and condition. (B) Exemplar current tracings illustrating use-dependent activation of Kv1.1-Kv1.2 dimeric channels in (i) ambient redox conditions or (ii) 666 µM DTT.
