Table 1 Thermodynamic parameters obtained from the ITC measurement of the binding between tylophorine analogs and Hsc70.

From: Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication

Compound

Protein

n

Kd (M)

ΔH (kCal/mol)

ΔS (cal/(mol·K))

DCB-3503

Hsc70 FL

0.41

2.8 ± 0.5

3079

35.7

DCB-3503

Hsc70 NBD

0.49

4.4 ± 0.9

5135

41.7

rac-Cryptopleurine

Hsc70 FL

0.57

3.1 ± 0.33

2019

32.0

rac-Cryptopleurine

Hsc70 NBD

1.06

2.7 ± 0.48

1905

31.9

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