Figure 2
From: Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice
Strain dependent changes in activity, anxiety, and marble burying found in AS mice. Open field assessment (OFA), elevated plus maze (EPM), and marble burying tests highlighted differences between Wt and AS mice, as well as differences in activity levels between background strains. (a,b) Both B6 and F1 hybrid AS mice showed significant hypoactivity in the open field through distance travelled and number of rearing episodes (vertical activity). (c) No differences were found between Wt and AS mice in the OFA measure of anxiety, % distance travelled in center zone. (d) B6 AS mice spent significantly less time in the closed arms of the EPM. (e) B6 and F1 hybrid AS mice buried significantly less marbles than Wt mice. The 129 mice showed low amounts of locomotor activity and marble burying compared to the B6 and F1 hybrid mice. For each strain, AS and Wt mice were compared with a Student’s t-test and data are shown as the mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
