Figure 3
From: Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice
AS mice from all three backgrounds performed poorly on motor testing. (a) Adult AS mice from all three backgrounds performed normally on the inverted screen test. (b) AS mice from the B6 and 129 backgrounds spent significantly less time on the wire hang test before fall compared to Wt mice. For each strain, AS and Wt mice were compared with a Student’s t-test and data are shown as the mean ± SEM, *p < 0.05, ***p < 0.001. (c–e) When tested with the accelerating rotarod protocol, B6 and F1 hybrid mice performed significantly worse than Wt mice. Rotarod results were analyzed with 2-way ANOVA and Bonferroni posttest; n = 15–16 mice/group; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
