Figure 4
From: Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice
AS mice showed strain-dependent learning and memory deficits. (a) The B6 Wt mice spent significantly more time with the novel object and were successful in the NOR task, while the B6 AS mice showed a similar preference for both objects. (b) Both the 129 AS and Wt mice performed poorly on NOR. (c) The F1 hybrid AS and Wt mice both showed a significant preference for the novel object. (d) The 129 AS mice showed a significant decrease in freezing behavior compared to Wt mice during the 24 hour context test indicating decreased fear memory. No significant difference in % time freezing was seen during the fear conditioning context test for the B6 and F1 hybrid mice. (e) Mice from all three backgrounds showed no difference in freezing behavior during cue testing 26 hours after fear conditioning training. For each strain, AS and Wt mice were compared with a Student’s t-test and data are shown as the mean ± SEM; n = 15–16 mice/group; *p < 0.05.
