Figure 7
From: Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice
Seizure induction with KA. (a,b) KA induction (25 mg/kg) in Wt and AS mice in the B6 background (n = 12–13 / group). No significant difference was found between B6 Wt and AS mice for time to reach the first clonus (tail/head/limbs) (a) or time to reach stage 4 or greater seizure (b). (c,d) KA induction (40 mg/kg) in Wt and AS mice in the 129 background (n = 11–12 / group). 129 AS mice exhibited a significantly lower latency to reach the first visible clonus of tail/head/limb (c) and stage 4 or greater seizure (d) compared to Wt littermates. (e,f) KA induction (35 mg/kg) in Wt and AS mice in the F1 background (n = 11–12 / group). F1 AS mice exhibited a significantly lower latency to reach the first visible clonus of tail/head/limb (e) compared to their Wt littermates. No significant difference was found between F1 Wt and AS mice for latency to stage 4 or greater seizure (f). Data are presented as the mean ± SEM; Student’s t-test was used to compare between AS and Wt mice; n = 11–13 mice/group; *p < 0.05.
