Figure 5

Renal tropism of MSC is suppressed by anti-inflammatory drugs and in COX2-KO mice. MSC do not routinely home to control kidneys (no pFUS, no drugs). Homing is enhanced ~5 fold in the pFUS-treated group (pFUS, no drugs). When anti-inflammatory drugs are administered prior to pFUS or pFUS is administered to COX2-KO mice without drug pretreatments, MSC tropism is suppressed compared to the pFUS alone group (p < 0.05). MSC homing to pFUS-treated kidneys of mice given ibuprofen was significantly greater than control kidneys (p < 0.05) but also significantly less than kidneys treated with pFUS alone. (n = 6 mice per treatment group; multiple comparisons made by ANOVA with Bonferroni post-hoc tests; symbols indicate statistically significant differences from groups with different or no symbol; Scale bars = 100 μm).