Table 3 Comparison of cognitive scores of healthy controls, cognitively preserved, and impaired patient groups.

From: Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder

Cognitive tests, adjusted mean scores (SE)

Healthy controls (n = 44)

Cognitively preserved patients (n = 50)

Patients with cognitive impairment (n = 23)

Verbal memory

 immediate recall

−0.38 (0.21)

−0.33 (0.18)

−1.36 (0.22)**,##

 delayed recall

−0.27 (0.19)

−0.19 (0.17)

−1.11 (0.21)**,###

 recognition

−0.28 (0.3)

−0.07 (0.26)

−1.32 (0.32)##

Visuospatial function

 RCFT copy score

−0.01 (0.24)

−0.07 (0.21)

−1.29 (0.26)**,##

Visual memory

 immediate recall

−0.21 (0.21)

−0.21 (0.18)

−2.45 (0.22)***,###

 delayed recall

−0.19 (0.21)

−0.35 (0.19)

−2.61 (0.23)***,###

 K−WAIS symbol digit modalities test

−0.41 (0.19)

−0.69 (0.17)

−1.62 (0.21)***,##

Digit Span

 forward

−0.19 (0.2)

0.07 (0.17)

−0.84 (0.22)##

 backward

0.03 (0.17)

−0.3 (0.15)

−0.92 (0.18)**,#

Stroop test

 simple

−0.22 (0.23)

−0.3 (0.2)

−1.26 (0.25)**,##

 interference

−0.24 (0.26)

−0.67 (0.23)

−2.03 (0.28)***,##

 COWAT

−0.42 (0.2)

−0.28 (0.17)

−1.65 (0.21)***,###

 PASAT

−0.43 (0.26)

−0.6 (0.23)

−3.02 (0.29)***,###

 Global z−score (sum of subtest scores)

−3.21 (1.44)

−3.99 (1.25)

−21.49 (1.56)***,###

  1. Abbreviations: BFI = Brief Fatigue Inventory; EDSS = Expanded Disability Status Scale; HCs = healthy controls; NA = not applicable; NMOSD = neuromyelitis optica spectrum disorder; SE = standard error. All comparisons of cognitive function were corrected for age, educational level, and depression level. Post hoc analysis was performed using Bonferroni correction.
  2. *p < 0.05 compared to healthy controls.
  3. **p < 0.01 compared to healthy controls.
  4. ***p < 0.001 compared to healthy controls.
  5. #p < 0.05 compared to cognitively preserved patients.
  6. ##p < 0.01 compared to cognitively preserved patients.
  7. ###p < 0.001 compared to cognitively preserved patients.