Figure 1 | Scientific Reports

Figure 1

From: iNOS promotes hypothalamic insulin resistance associated with deregulation of energy balance and obesity in rodents

Figure 1

ICV GSNO modulates energy homeostasis. Immunoblot analysis for total iNOS in hypothalamus animals treated with GSNO (A) Cumulative food intake (B), body weight change (C) and epididymal fat weight (D) of GSH or GSNO treated mice. Biotin switch method analysis for IRβ and Akt S-nitrosation in mice treated with GSNO (E). Cumulative food intake (F) and body weight change (G) in GSH, PBS  or GSNO treated iNOS knockout mice. Biotin switch method analysis for IRβ and Akt S-nitrosation in iNOS knockout mice treated with GSNO (H) Western Blotting analysis for insulin-induced phosphorylation of IRβ and Akt in iNOS knockout mice treated with GSH or GSNO (I). Data are presented as mean ± SEM, *p < 0.05 vs. GSH -injected rats; **p < 0.01 vs. other groups (n = 10–15 animals per group).

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