Figure 1 | Scientific Reports

Figure 1

From: Suppression of GRK2 expression reduces endothelial dysfunction by restoring glucose homeostasis

Figure 1

GRK2 is reduced by GRK2 siRNA delivery in liver. (A) Experimental protocol for ob/ob mice: ob/ob mice or lean (control) mice were treated with GRK2 siRNA or control siRNA by hydrodynamic delivery as indicated (intravenously, 2 mg/kg). (B) Western blot analysis of GRK2 in the liver, aorta and heart, respectively. Top is the representative Western blots for GRK2 protein, and bottom is the total GRK2 expression. Ratios were calculated for the optical density of GRK2 over that of β-actin. Values are mean ± SE; n = 6. * p < 0.05, ** p < 0.01 vs. control siRNA-transfected lean mice (lean-cont siRNA); † p < 0.05 vs. control siRNA-transfected ob/ob mice (ob/ob-cont siRNA) by one-way analysis of variance.

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