Figure 4

Suppression of hepatic GRK2 results in vascular function. Concentration response curves for clonidine (A), insulin (B), acetylcholine (ACh; C), sodium nitroprusside (SNP; D), and phenylephrine (PE; E) in aortas from control siRNA-transfected lean mice (lean-cont si), control siRNA-transfected ob/ob mice (ob/ob-cont si), and GRK2 siRNA-transfected ob/ob mice (ob/ob-GRK2 si). Values are mean ± SE; n = 4–5. ^*** p < 0.001 vs. lean-cont si; ^†† p < 0.01, ^††† p < 0.001 vs. ob/ob-cont si by repeated measures two-factor ANOVA test followed by Bonferroni correction for multiple comparisons.