Table 2 Association of CDKAL1 rs7756992 with DR in Chinese patients with type 2 diabetes.

From: CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes

 

n (case/control)

Minor allele frequency

OR (95% CI)

P  a

Control subjects

Case subjects

DR vs controls

313/238

0.475

0.428

0.697 (0.522, 0.931)

0.0145

DR and DKD vs DKD

281/419

0.499

0.414

0.707 (0.547, 0.913)

0.0079

Validation cohort (1)

380/613

0.453

0.43

0.890 (0.728–1.088)

0.26

Validation cohort (2)

545/929

0.470

0.439

0.874 (0.749–1.020)

0.09

Meta-analysis

1519/2199

0.471

0.43

0.824 (0.743–0.914)

2.46 × 10 −4

  1. DKD = diabetic kidney disease; DR = diabetic retinopathy.
  2. P values < 0.05 are shown in bold.
  3. aAdjusted for duration of diabetes, HbA1c, systolic blood pressure, diastolic blood pressure, body mass index.
  4. The OR with 95% CI shown is for the minor allele.
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