Table 2 The most important transcriptional factors of rMASP-1 induced IR genes.

GATA2

GATA binding protein 2

Required for preproendothelin-1 (PPET-1) and VCAM-1 gene expresson in endothelial cells^{39, 40}

TNFα

14

AR

androgen receptor

Inhibition of TNFα-induced VCAM-1 expression and NF-κB activation⁴¹ and increasing human monocyte adhesion to vascular endothelium⁴²

Testosterone (T) and 5α-dihydrotestosterone (5αDHT)

13

NFKB1

nuclear factor kappa B subunit 1

Regulates expression of E-Selectin, VCAM-1, ICAM-1, IL-6, IL-8, MCP-1 in endothelial cells^{1, 3, 43}.

TNFα and Thrombin

10

ETS1

ETS proto-oncogene 1

Regulates cyclin-dependent kinase inhibitor (p21^CIP), PAI-1, VCAM-1, and MCP-1 in endothelial cells⁴⁴.

Ang II, PDGF-BB, and TNFα

8

FOXC1

forkhead box C1

Induces CXCR4 expression in endothelial cells, controlling CXCL12-stimulated migration⁴⁵.

CXCL12

8

RELA

RELA proto-oncogene, NF-kB subunit

Regulates expression of E-Selectin, VCAM-1, ICAM-1, IL-6, IL-8, MCP-1 in endothelial cells^{1, 3, 43}.

TNFα and Thrombin

8

FOXL1

forkhead box L1

Regulates the proliferation and differentiation of gastrointestinal epithelium⁴⁶.

Induced during hepatic stellate cell activation

7

GATA1

GATA binding protein 1

Regulates expression of angiogenic factor with G-patch and FHA domains 1 (AGGF1) in endothelial cells⁴⁷.

Erythropoietin (Epo)

7

TP53

tumor protein P53

Upregulates developmental endothelial locus-1 (Del-1) in endothelial cells, which inhibits leukocyte recruitment⁴⁸.

Variety of cellular stresses

7

FOXP3

forkhead box P3

Specifies the Treg cell lineage⁴⁹.

Activation of CD4 + T cells

6

HIF1A

hypoxia inducible factor 1 alpha subunit

Induces endothelins ET-1 and ET-2, and VEGF in endothelial cells⁵⁰.

Hypoxia

6

JUN

Jun proto-oncogene, AP-1 transcription factor subunit

Forms AP-1, the early response transcription factor in endothelial cells⁵¹.

TNFα, Thrombin

6