Figure 6
From: miR-181a involves in the hippocampus-dependent memory formation via targeting PRKAA1
miR-181a was involved in LTM formation following CFC and OLT by regulating PRKAA1. (a,b) Effects of different doses of the PRKAA1 agonist and inhibitor on the freezing response (a) and discrimination index (b) of mice 24 h after CFC or OLT training. *p < 0.05, **p < 0.01, compared with the vehicle group. n = 7 per group. (c–d) Freezing response when tested 24 h after CFC training. *p < 0.05, **p < 0.01, compared with the naïve group. # p < 0.05, compared with the CFC + miR-181a agomir group or CFC + miR-181a antagomir group. (e–f) Discrimination index 24 h after OLT training. *p < 0.05, **p < 0.01, compared with the naïve group. # p < 0.05, compared with the OLT + miR-181a agomir group or OLT + miR-181a antagomir group. CC, compound C. n = 8 per group. All values are presented as means ± SEM.
