Figure 4

Enrichment analysis of biological processes using DAVID software. (A) Cellular compartment enrichment analysis of biological processes on proteins that were down regulated in cell layer of lung-MSC (n = 3) compared to bone marrow-MSC (n = 3) using the DAVID program. Processes with a FDR >10% containing more than two proteins are presented. The expression of proteins involved in negative regulation of cell growth (B,C,D,E) and negative regulation of proliferation (C,D,F,G,H,I) were measured using quantitative proteomic. Data are presented as normalized intensity and mean (±SD). Neg, negative; regl, regulation; apop, apoptosis; sign, signaling; ox, oxidative; DCBD2, Discoidin (CUB and LCCL domain-containing protein 2); PML, Promyelocytic leukemia protein; GDN, Glia-derived nexin; PP2AA, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; IBP7, Insulin-like growth factor-binding protein 7; TES, Testin; ATS1, A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS1); CP1B1, Cytochrome P450 1B1; BM, bone marrow-derived MSC; Lung, lung-derived MSC. The p-values were determined using RStudio with Benjamini and Hochberg correction for multiple testing.