Table 2 Concentrations of bile acids in sera and liver after rats treated with Geniposide for 3 days.

From: Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation

 

control

Geniposide

100 mg/kg

300 mg/kg

Sera (μg/ml)

T-α-MCA

0.0627 ± 0.0551

0.0413 ± 0.0294

0.145 ± 0.0772*

THDCA

0.183 ± 0.203

0.138 ± 0.0539

0.126 ± 0.0355

TCA

0.138 ± 0.133

0.123 ± 0.0937

0.712 ± 0.571*

TCDCA

0.0448 ± 0.0259

0.0669 ± 0.0152*

0.124 ± 0.0260***

TDCA

0.0525 ± 0.0433

0.0387 ± 0.0295

0.109 ± 0.0987

GUDCA

0.0611 ± 0.00289

0.0612 ± 0.00328

0.0615 ± 0.00155

GHDCA

0.445 ± 0.633

0.186 ± 0.232

0.0735 ± 0.0558

GCDCA

0.0597 ± 0.0648

0.0380 ± 0.0453

0.0405 ± 0.0292

GDCA

0.119 ± 0.137

0.0861 ± 0.140

0.0750 ± 0.0595

GCA

0.988 ± 1.078

1.557 ± 1.655

1.871 ± 1.147

β-MCA

0.460 ± 0.434

0.788 ± 0.486

1.128 ± 0.330**

CA

0.555 ± 0.781

0.886 ± 0.744

1.477 ± 1.256

UDCA

0.0817 ± 0.0547

0.0447 ± 0.0249

0.0576 ± 0.0255

HDCA

1.492 ± 1.066

0.619 ± 0.182*

0.427 ± 0.123*

CDCA

0.0903 ± 0.147

0.105 ± 0.0939

0.135 ± 0.142

DCA

0.137 ± 0.0630

0.146 ± 0.109

0.165 ± 0.103

Liver (μg/g)

T-α-MCA

36.112 ± 15.073

36.983 ± 16.058

61.974 ± 14.241**

THDCA

20.798 ± 10.187

11.927 ± 4.966*

7.730 ± 2.746**

TCA

47.005 ± 21.610

65.257 ± 24.042

126.849 ± 32.844***

TCDCA

4.269 ± 2.075

3.785 ± 1.578

11.199 ± 6.825*

TDCA

12.250 ± 8.509

8.903 ± 3.776

11.964 ± 8.065

GUDCA

0.173 ± 0.189

0.136 ± 0.152

0.139 ± 0.133

GHDCA

2.955 ± 3.941

1.190 ± 1.466

0.395 ± 0.523

GCA

12.660 ± 11.362

17.873 ± 16.076

21.914 ± 16.195

GCDCA

0.393 ± 0.499

0.291 ± 0.402

0.349 ± 0.301

GDCA

1.754 ± 1.608

0.949 ± 0.995

0.755 ± 0.732

β-MCA

0.413 ± 0.495

0.288 ± 0.235

0.595 ± 0.376

CA

0.145 ± 0.167

0.0876 ± 0.0864

0.779 ± 1.624

HDCA

0.470 ± 0.420

0.0817 ± 0.0324*

0.0804 ± 0.0346*

CDCA

0.0437 ± 0.0270

0.0363 ± 0.0120

0.0429 ± 0.0259

  1. Data are presented as means ± SD concentrations in sera and liver measured using UPLC-MS/MS of 7–8 rats. *p < 0.05, **p < 0.01, ***p < 0.001, compared with the control group of same bile acid.