Figure 1
From: Establishing PNB-qPCR for quantifying minimal ctDNA concentrations during tumour resection
Curve progressions of cfDNA, ctDNA, and DNase 1 activity reduction over the course of surgery. In contrast to the cfDNA values, which steadily increased over the whole course of surgery, ctDNA concentrations decreased sharply during surgery and only increased briefly after resection of pathological tissues and then again gradually in the days following surgery. Changes in DNase 1 AR were inversely correlated to cfDNA development. LOQ and LOD in dashed lines refer to ctDNA values only. Phases of surgery are coloured in grey. Time intervals between samples are 20 minutes if not specified differently. The amount of taken samples was dependent on progress of operation.
