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Figure 1

From: Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts

Figure 1

Alteration of carbohydrate catabolic pathway during syncytialization of human placental trophoblasts. (A) Hematoxylin staining showing morphological changes of human placental trophoblasts during syncytialization. The trophoblasts were collected before (3 h) and after (48 h) syncytialization for transcriptomic analyses. (B) A diagram depicting the changes of genes encoding enzymes involved in glycolysis and tricarboxylic acid (TCA) cycle during syncytialization with transcriptomic analyses. Red: up-regulated genes, Green: down-regulated gene. (C) Changes in the values of Reads per Kilobases per Millionreads (RPKM) of the differentially expressed genes during syncytialization. n = 3. (D) and (E) Changes in the cellular lactate (n = 5, D) and ATP levels (n = 3, E) during syncytialization. *P < 0.05; **P < 0.01 against 3 hours.

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