Figure 4 | Scientific Reports

Figure 4

From: Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts

Figure 4

Role of PDK4 in syncytiotrophoblast functions. (A) and (B) The abundance of 11β-HSD2 mRNA (n = 4, A) and protein (n = 3, B) and β-hCG mRNA (n = 4, A) was significantly increased by siRNA-mediated knock-down of PDK4 expression. Randomly scrambled siRNA served as negative control (Nc). (C) and (D) Over-expression of PDK4 significantly decreased the abundance of 11β-HSD2 mRNA (n = 4, C) and protein (n = 3, D) and β-hCG mRNA (n = 4, C). *P < 0.05; **P < 0.01; ***P < 0.001 against Nc (A and B) or Vehicle (C and D).

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