Table 2 The SNPs associated with female fertility traits detected by validating candidate SNPs from Chinese Holsteins using Nordic Holstein data.

From: Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins

BTA

Position1(bp)

SNP

Trait2

MAF3

Chinese Holsteins

MAF3

Nordic Holsteins

Genes5

P-value

Effect size4(%)

P-value

Effect size4(%)

3

16,179,998

rs109155222

IFLc

0.40

4.33E-03

1.75

0.43

3.41E-05

0.30

IL6R

3

25,763,148

rs110094798

IFLc

0.24

3.30E-03

1.95

0.20

3.12E-05

0.35

FAM46C, MAN1A2

3

26,949,196

rs109368837

IFLc

0.22

2.78E-03

2.09

0.20

7.67E-05

0.31

CD58, ATP1A1

3

66,768,945

rs42361598

IFLc

0.42

3.94E-03

1.69

0.44

4.85E-05

0.31

PTGFR, GIPC2

4

47,737,653

rs110127380

CRh

0.47

4.40E-03

3.69

0.41

7.90E-05

0.37

NAMPT, PIK3CG

4

67,145,895

rs41589544

ICF

0.07

1.51E-04

0.85

0.12

5.19E-05

0.21

CHN2

6

87,600,892

rs109377247

IFLc

0.33

6.51E-04

2.31

0.33

8.67E-06

0.35

ENSBTAG00000007816, AMTN

10

29,538,245

rs42563243

ICF

0.44

2.62E-03

0.65

0.38

4.01E-05

0.32

ENSBTAG00000021414 ENSBTAG00000025634

10

83,435,322

rs43642952

CRc

0.16

3.07E-03

1.56

0.18

1.41E-05

0.29

ENSBTAG00000005395, ENSBTAG00000025385

11

83,938,054

rs29026760

ICF

0.26

3.70E-03

0.62

0.28

5.08E-05

0.28

FAM84A, ENSBTAG00000019284

11

85,906,433

rs110195627

ICF

0.23

2.90E-03

0.66

0.26

1.35E-05

0.31

TRIB2, LPIN1

13

30,713,329

rs109193608

IFLc

0.35

2.68E-03

1.89

0.42

7.55E-06

0.33

FAM188A, PTER

13

31,364,982

rs110068451

ICF, IFLc

0.34

3.44E-03, 9.21E-04

0.58, 2.18

0.41

6.70E-11, 1.33E-06

0.69, 1.12

RSU1

13

31,416,451

rs109492780

IFLc

0.38

5.90E-04

2.53

0.43

8.11E-09

0.56

RSU1

13

31,524,626

rs41604666

IFLc

0.49

4.41E-04

2.64

0.48

4.37E-07

0.46

RSU1

13

32,802,426

rs41609782

IFLc

0.40

3.26E-03

1.82

0.41

1.69E-05

0.31

SLC39 A12, CACNB2

13

32,831,454

rs109983109

ICF, IFLc

0.41

8.03E-04, 3.11E-03

0.81, 1.86

0.45

6.64E-10, 4.95E-06

0.66, 0.34

SLC39A12, CACNB2

13

33,501,056

rs109621404

IFLc

0.46

3.90E-03

1.95

0.40

1.65E-08

0.60

EPC1

13

52,447,531

rs109573317

CRc

0.35

4.58E-03

1.37

0.30

4.07E-05

0.29

SLC4A11

15

27,235,378

rs110869861

ICF

0.27

4.94E-03

0.50

0.23

9.02E-06

0.42

CADM1, BUD13

16

53,070,045

rs41580862

ICF

0.27

4.14E-04

0.84

0.26

8.50E-05

0.30

SLC25A34

16

53,097,936

rs110199510

ICF

0.27

5.89E-04

0.79

0.26

8.50E-05

0.30

PLEKHM2

16

57,419,757

rs41581444

ICF

0.31

5.01E-04

0.87

0.36

3.89E-05

0.30

ENSBTAG00000027809, GPR52

17

67,245,920

rs41848120

CRh

0.48

1.28E-04

7.32

0.46

3.87E-05

0.41

PIWIL3

17

72,448,619

rs41634418

ICF

0.35

3.57E-03

0.59

0.34

5.79E-06

0.40

PISD

18

48,150,900

rs110543856

ICF, IFLc

0.15

2.60E-03, 2.99E-04

0.65, 2.80

0.13

5.84E-08, 3.96E-07

0.61, 0.50

SIPA1L3

21

41,383,298

rs29012716

ICF

0.16

4.96E-04

0.81

0.12

5.23E-05

0.40

PRKD1, G2E3

21

47,273,394

rs110964123

ICF

0.40

2.13E-03

0.63

0.38

7.52E-05

0.30

NKX2-8, PAX9

23

50,036,208

rs110076231

CRc

0.38

1.27E-03

1.95

0.45

1.31E-04

0.25

PRPF4B, PXDC1

23

51,938,161

rs29027634

IFLc, CRc

0.36

3.25E-03, 4.73E-03

1.84, 1.45

0.37

8.89E-05,1.26E-04

0.27, 0.26

EXOC2

24

30,468,614

rs109722348

ICF

0.39

2.98E-03

0.66

0.38

6.27E-05

0.31

AQP4, KCTD1

24

30,513,490

rs110839120

ICF

0.39

2.65E-03

0.68

0.38

1.07E-04

0.28

AQP4, KCTD1

24

33,624,891

rs109629413

ICF

0.48

2.35E-03

0.62

0.47

7.81E-05

0.30

TMEM241

  1. 1The base pair position in the BTA (Bos taurus autosome).
  2. 2CRh = conception rate at first insemination in heifers; ICF = interval from calving to first insemination; IFLc = interval from first to last insemination in cows; CRc = conception rate at first insemination in cows.
  3. 3Minor allele frequency of the validated SNP.
  4. 4The percentage of genetic variance explained by the most significant SNP.
  5. 5Genes harbor or closest to the significant SNP.