Table 1 Top 5 Upstream Regulators, Disease and Bio functions modulated during EMT in Huh7.5:Huh7.5M cells, as predicted by IPA.
I. Top Upstream Regulators | ||
|---|---|---|
Upstream Regulator | P- value of overlap | Predicted Activation |
HNF4A | 1.04*10−9 | Inhibited |
HNF1A | 6.83*10−9 | Inhibited |
PKD1 | 6.98*10−9 | Inhibited |
CTNNB1 | 3.84*10−7 | Activated |
MGEA5 | 3.32*10−5 | Inhibited |
II. Top Disease and Bio functions | ||
A. Diseases and Disorders | ||
Name | P -value range | Number of molecules |
Organismal injury and abnormalities | 1.16*10−4–5.12*10−24 | 1651 |
Connective tissue disorder | 1.14*10−4–6.65*10−21 | 524 |
Skeletal and muscular disorder | 1.14*10−4–6.65*10−21 | 622 |
Neurological disease | 6.00*10−5–2.81*10−18 | 674 |
Developmental disorder | 9.754*10−5–4.11*10−17 | 732 |
B. Molecular and cellular functions | ||
Name | P- value range | Number of molecules |
Cellular assembly and organization | 1.32*10−4–1.26*10−20 | 611 |
Cellular function and maintenance | 1.32*10−4–1.26*10−20 | 1097 |
Cellular development | 1.33*10−4–1.90*10−20 | 1265 |
Cellular morphology | 1.13*10−4–5.80*10−20 | 1128 |
Cellular growth and proliferation | 5.70*10−4–1.32*10−19 | 1432 |
C. Physiological system development and function | ||
Name | P- value range | Number of molecules |
Embryonic development | 1.29*10−4–1.40*10−28 | 1286 |
Organismal development | 1.29*10−4–1.40*10−28 | 1860 |
Organismal survival | 3.22*10−4–1.78*10−23 | 1291 |
Connective tissue development and function | 1.25*10−4–1.10*10−22 | 858 |
Skeletal and muscular development and function | 1.24*10−4–1.10*10−22 | 805 |
