Figure 7
ASIC3- or TRPV1-deficiency or shTDAG8 knockdown reduces synovial CD68+ macrophages at 12 weeks Samples of ipsilateral joints from WT, ASIC3−/−, TRPV1−/−, shTDAG knockdown mice at 4, 8, 12 weeks were stained with CD68 (A,C) or CD80 (B,D) antibodies. Synovial sublining regions are shown in (A,B). Magnification, 100x. The number of cells in 100 × 100 μm2 was calculated and presented as histograms (C,D). #p < 0.05, ###p < 0.001, compared with 4w; *p < 0.05, ***p < 0.001, compared with WT by one-way ANOVA.
