Table 3 Differences in the IVIM-DWI parametric values between the pCR and non-pCR groups and between the GR and PR groups.

From: Intravoxel incoherent motion diffusion-weighted imaging for discriminating the pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Parameter

pCR (n = 10)

non-pCR (n = 32)

P

GR (n = 15)

PR (n = 27)

P

preADC (x10−3 mm2/s)

1.20 ± 0.18

1.25 ± 0.13

0.406

1.21 ± 0.16

1.25 ± 0.13

0.503

preD (×10−3 mm2/s)

0.88 ± 0.13

0.91 ± 0.11

0.154

0.92 ± 0.15

0.90 ± 0.09

0.937

preD* (×10−3 mm2/s)

74.64 ± 38.72

47.87 ± 31.71

0.020*

60.54 ± 40.47

50.74 ± 31.79

0.431

pref

0.21 ± 0.04

0.18 ± 0.04

0.045*

0.20 ± 0.04

0.18 ± 0.04

0.059

postADC (×10−3 mm2/s)

1.94 ± 0.32

1.83 ± 0.37

0.423

1.93 ± 0.29

1.82 ± 0.40

0.282

postD (×10−3 mm2/s)

1.64 ± 0.25

1.36 ± 0.24

0.004*#

1.61 ± 0.26

1.32 ± 0.22

0.002*#

postD* (×10−3 mm2/s)

62.63 ± 42.50

46.79 ± 32.16

0.192

60.72 ± 38.22

44.92 ± 32.45

0.112

postf

0.23 ± 0.15

0.21 ± 0.07

0.805

0.22 ± 0.12

0.21 ± 0.07

0.470

∆%ADC (%)

63.19 ± 24.36

47.96 ± 32.79

0.042*

60.34 ± 25.05

46.72 ± 33.89

0.032*

∆%D (%)

88.51 ± 24.54

48.82 ± 22.25

 < 0.001*#

77.08 ± 27.85

47.83 ± 22.91

0.001*#

∆%D* (%)

−4.98 ± 54.85

60.24 ± 228.51

0.738

57.91 ± 187.87

37.38 ± 208.09

0.181

  1. *Significance before multiple comparison correction; #significance after multiple comparison correction (P [2] = 0.004 < i*q/m = 2*0.05/12 = 0.0083 for the comparisons between the pCR and non-pCR groups, and P [2] = 0.002 < i*q/m = 2*0.05/12 = 0.0083 for the comparisons between the GR and PR groups) according to the Benjamini- Hochberg procedure21; IVIM-DWI,intravoxel incoherent motion diffusion-weighted imaging; pCR, pathological complete response; non-pCR, non-pathological complete response; GR, good response; PR, poor response; ADC, apparent diffusion coefficient; D, pure diffusion coefficient; D*, pseudo-diffusion coefficient; f, perfusion fraction.
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