Figure 2
From: Distribution bias and biochemical characterization of TOP1MT single nucleotide variants

The V256I and R525W variants correspond to highly conserved regions of TOP1MT across species. (A) Alignment of the TOP1 and TOP1MT sequences corresponding to the V256I site. (B) Alignment of the TOP1 and TOP1MT sequences corresponding to the R525W site. Hs, Homo sapiens; Pt, Pan troglodytes; Rn, Rattus norvegicus; Mm, Mus musculus; Gg, Gallus gallus; Ac, Anolis carolinensis; Cp, Chrysemys picta.