Figure 6 | Scientific Reports

Figure 6

From: miRNA-584-3p inhibits gastric cancer progression by repressing Yin Yang 1- facilitated MMP-14 expression

Figure 6

YY1 and miR-584-3p are positively or inversely correlated with MMP-14 levels in gastric cancer tissues. (a) Immunohistochemical staining showing the expression of YY1 and MMP-14 in the tumor cells of gastric cancer specimens (arrowheads, brown). Scale bars: 100 μm. (b) Western blot assay indicating the protein levels of YY1 and MMP-14 in gastric cancer tissues with different differentiation, and those in normal gastric mucosa. (c) Real-time quantitative RT-PCR showing the transcript levels of YY1, MMP-14, and miR-584-3p in normal gastric mucosa (n = 80) and gastric cancer tissues (n = 80). (d) The correlation between MMP-14 transcript levels and YY1 or miR-584-3p expression in gastric cancer tissues (n = 80). (e) Kaplan–Meier survival plots of 60 well-defined gastric cancer cases with high or low expression of miR-584-3p, YY1, or MMP-14. *P < 0.01 vs. normal.

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