Figure 4
Advantage of non-switching behavior under homogeneous ECM conditions. The figure shows the average migration distance dp of switching and non-switching populations depending on the switch ratio α/β for different homogeneous ECM conditions: (a) homogeneous, low ECM resistance modeled by μ(r 1,r 2) = 0.1 and (b) homogeneous, high ECM resistance with μ(r 1,r 2) = 0.9. The blue line represents the switching populations, the black lines display non-switching populations with different M-cell fraction \(\gamma \in \mathrm{\{0,0.3,0.7,1\}}\). Each simulation is run with 50 cells. Simulations are evaluated after 200 Monte Carlo steps, averaged over 50 independent simulations. The errorbars show the standard deviation of the average migration distance d p between the simulations. The standard deviation within the simulations is shown in Supplementary Fig. S5. Simulation parameters are c M /c A = 0.25, κ = 1, δ = 0.1.
