Figure 1 | Scientific Reports

Figure 1

From: An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum

Figure 1

Timeline (from top to bottom) for neuronal differentiation of mouse embryonic stem cells (ES cells) into an expandable population of cerebellar neurons. Graphs show the stem cell stage (top panel: ES stage), the induction stage of embryoid bodies (EB) in SFEBq culture (EB differentiation stage), an intermediate expansion or proliferation stage of neural progenitor cells (NPCs) through stable passaging on laminin in NPCs medium (NPC expansion stage), and finally the maturation in vitro in NS21 medium (in vitro maturation stage) and maturation in adult wild type mouse cerebella (bottom panel: in vivo maturation stage). P2 indicates passage 2 (of expansion stage); Arac indicates cytosine β-D-arabinofuranoside; Scale bars indicate 100 μm.

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