Table 2 Univariate and multivariate analysis of routine laboratory data in the training set associated with further analysis of risk factors.

From: A Simple Noninvasive Index Can Predict Hepatocellular Carcinoma in Patients with Chronic Hepatitis B

Routine laboratory data

HCC versus Non-cancer Controla

Univariate

Multivariate

Furtherb

P

Mean ± SD

B

S.E.

P

B

S.E.

P

White cell count (×109/L)

<0.001

(5.0 ± 2.0 versus 6.0 ± 1.9)

      

Red blood count (×1012/L)

<0.001

(4.3 ± 0.8 versus 4.8 ± 0.6)

      

Platelet count (×109/L)

<0.001

(132 ± 73 versus 220 ± 76)

−0.012

0.003

0.001

−0.02

0.003

<0.001

Lymphocyte (×109/L)

<0.001

(1.3 ± 0.7 versus 2.1 ± 0.7)

−1.07

0.398

0.007

   

Monocyte (×109/L)

0.524

(0.4 ± 0.2 versus 0.5 ± 0.2)

      

Neutrophil (×109/L)

0.362

(3.1 ± 1.5 versus 3.3 ± 1.5)

      

AFP (ng/ml)

<0.001

(372.6 ± 475.9 versus 35.9 ± 114.1)

0.004

0.001

<0.001

0.01

0.001

<0.001

AST (U/L)

0.134

(82 ± 114 versus 127 ± 237)

      

ALT (U/L)

0.04

(67 ± 101 versus 202 ± 490)

−0.006

0.002

0.002

−0.01

0.002

0.003

GGT (U/L)

<0.001

(147.3 ± 202.3 versus 67.2 ± 76.6)

      

ALP (U/L)

<0.001

(144.8 ± 74.0 versus 96.4 ± 44.1)

0.017

0.005

0.002

   

TBIL (umol/L)

0.417

(37.1 ± 62.0 versus 46.3 ± 87.2)

      
  1. aNon-cancer Control group includes healthy participants and patients with CHB. bFurther analysis means for simplification, the 5-variable panel was simplified to a 3-variable panel without losing accuracy after repeated verification.