Figure 5
From: Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma
Assessment of central airway remodelling with EBUS. (a) Representative image of a central airway obtained with EBUS in a horse with asthma. Thin white arrows indicate the 3 hyperechoic layers of the bronchial wall representing, from the airway lumen going outwards, the bronchial epithelium, the inner, and the outer borders of the bronchial cartilage. The distance between the thick yellow arrows illustrates the thickness of L2. (b) EBUS-assessed central airway remodelling in study I. (c) Correlation between EBUS-assessed central airway remodelling and peripheral ASM remodelling assessed at histology at baseline (T0) in study I. Each symbol represents one horse (mean value of multiple measures performed). L2: second layer; EBUS: endobronchial ultrasound; ASM: airway smooth muscle; Pi: internal perimeter. *Different from baseline of the same group (p < 0.05); §difference between groups at the time point indicated (p < 0.05).
