Figure 2 | Scientific Reports

Figure 2

From: Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease

Figure 2

Increased lipid peroxidation is normalized by KH176. Representative images (20X) of 4HNE staining of the cerebral cortex (A,C,E,G) and external capsule (B,D,F,H) for a control, Ndufs4 −/− vehicle-treated, Ndufs4 −/− KH176-treated mouse and negative control. Arrow indicates the positive staining in the external capsule. (I,J) Quantification of the 4HNE staining of control (white bar), Ndufs4 −/− mice vehicle (gray bar) and KH176-treated (black bar) (PD > 42). 4HNE (a.u.) expressed as mean ± SEM (n = 4). Multivariate ANOVA (**p < 0.01, *p < 0.05).

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