Figure 4 | Scientific Reports

Figure 4

From: Chemotherapy with cisplatin: insights into intracellular pH and metabolic landscape of cancer cells in vitro and in vivo

Figure 4

Effects of cisplatin on HeLa tumors in mice. (A) Tumor volume dynamics in response to cisplatin. Mice (●, ■) were administrated i.p. with 5 mg/kg cisplatin, totaling 11 doses, for 4 weeks, starting from day 7 after tumor challenge (day 0). Control mice (○, □) received PBS. Mean ± SD, n = 3. Tumor volumes from individual mice were normalized to the values measured on day 7. *Statistically significant difference between treated and untreated HeLa tumors, p ≤ 0.05. #Statistically significant difference between treated and untreated HeLa-SypHer2 tumors, p ≤ 0.05. (B,C) Post-treatment histopathology of HeLa-SypHer2 and HeLa tumors. H&E-staining. Enlarged regions are indicated by the yellow squares on the lower-magnification panel (210 × 280 µm, original magnification ×20). Higher-magnification images (60 × 80 µm, original magnification ×40) are shown on the right. Bar is 100 µm.

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