Figure 4 | Scientific Reports

Figure 4

From: Combinatory repair strategy to promote axon regeneration and functional recovery after chronic spinal cord injury

Figure 4

aFGF and ChABC promote astrocyte and Schwann cell integration at the interface of PNG and caudal spinal cord. Representative confocal images of sagittal sections showing PNG- (left column) or PNG+aFGF+ChABC- (right column) treated spinal cords 40 weeks post-injury. The top row shows low magnification of GFAP staining (white). Note the extensive migration of GFAP+ astrocytes throughout the PNG (GFAP-negative area) only following PNG+aFGF+ChABC treatment. Scale bar, 500 µm. Bottom row shows high magnification of PNG p75+ Schwann cells (red) and spinal cord GFAP+ astrocytes (green). Note the migration and integration of Schwann cells and astrocytes, including overlapping spatial domains (yellow), only following PNG+aFGF+ChABC treatment. Scale bar, 100 µm.

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