Figure 4 | Scientific Reports

Figure 4

From: Combinatory repair strategy to promote axon regeneration and functional recovery after chronic spinal cord injury

Figure 4The alt text for this image may have been generated using AI.

aFGF and ChABC promote astrocyte and Schwann cell integration at the interface of PNG and caudal spinal cord. Representative confocal images of sagittal sections showing PNG- (left column) or PNG+aFGF+ChABC- (right column) treated spinal cords 40 weeks post-injury. The top row shows low magnification of GFAP staining (white). Note the extensive migration of GFAP+ astrocytes throughout the PNG (GFAP-negative area) only following PNG+aFGF+ChABC treatment. Scale bar, 500 µm. Bottom row shows high magnification of PNG p75+ Schwann cells (red) and spinal cord GFAP+ astrocytes (green). Note the migration and integration of Schwann cells and astrocytes, including overlapping spatial domains (yellow), only following PNG+aFGF+ChABC treatment. Scale bar, 100 µm.

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