Figure 4 | Scientific Reports

Figure 4

From: Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer’s disease progression

Figure 4

Signaling pathways disrupted in the OB across AD grading. Levels and residue-specific phosphorylation of MKK3/6 (a), p38 MAPK, ATF2, and HSP27 (b), PDK1, and PKC (c) in the OB across AD phenotypes. Equal loading of the gels was assessed by Ponceau staining and hybridization with a GAPDH specific antibody. Right panels show histograms of band densities. Data are presented as mean ± SEM from 5 independent OB samples per group. *P < 0.05 vs control group; **P < 0.01 vs control group. Representative Western blot gels (n = 3/experimental group) are shown. Full-length blots/gels are presented in Supplementary information.

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