Figure 2 | Scientific Reports

Figure 2

From: Nanomechanics of multidomain neuronal cell adhesion protein contactin revealed by single molecule AFM and SMD

Figure 2

Typical force-extension curves with saw-tooth patterns observed for CNTN4 in smFS AFM. Red crosses and blue rectangles indicate unfolding patterns associated with the respective domains IgC2 and FnIII. Displayed numbers (in nm) above each peak are the unfolding length resulting from WLC model fitting. Green arrow points a characteristic hump which appears in FnIII modules. (a) Examples of force-extension profiles with sequential unfolding of short (red crosses) and long (blue rectangles) elongations are displayed in red and blue boxes (right side); (b) Example of non-sequential unfolding of short and long elongations with at least 9 unfolding peaks. Green square indicates an event that most probably arises from alternative unfolding of FnIII1 module.

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